Krylov Vyacheslav Antonovich

Krylov V.A., Kulikov A.Y., Yagudina R.I. 740

Infertility is successfully treated by IVF and ICSI methods. One of the most important stages in IVF protocol is control ovarian stimulation (COS). There are recombinant and menopausal drugs to develop and mature oocyte. In this article was compared the economic efficiency of follitropin-alpha+lutropin-alpha vs follitropin-alpa+menotropin vs menotropin based on cost-effectiveness, budget impact analysis. Folliropin-alpha+lutropin-alpha cost of treating per one patient estimate 51 520 rubles, menotropin – 49 104 rubles, follitropin- alpa+menotropin - 61 298 rubles. Cost-effectiveness analysis, provided on the number of retrieved oocytes, rate of implantation and rate of clinical pregnancy, shown that follitropin-alpha+lutropin-alpha is dominant therapy. According to the results of the budget impact analysis, the increasing use of follitropin- alpha+lutropin-alpha on the market to 51.5% will save 29.2 million rubles.

Krylov V.A. 290

This article describes the currently used methods of indirect comparisons. The possibilities of using adjusted indirect comparison by the «Bucher method» are considered in detail. An indirect comparison of menotropin vs follitropin - alpha + menotropin is performed on the K. Buhler clinical trial. The indirect comparison showed no statistically significant differences between menotropin and follitropin-alpha + menotropin: OR=0.92 (0.68; 1.24), RR=0.93 (0.71;1.21).

Krylov V.A., Kulikov A.Y., Yagudina R.I. 740

Infertility is successfully treated by IVF and ICSI methods. One of the most important stages in IVF protocol is control ovarian stimulation (COS). There are recombinant and menopausal drugs to develop and mature oocyte. In this article was compared the economic efficiency of follitropin-alpha+lutropin-alpha vs follitropin-alpa+menotropin vs menotropin based on cost-effectiveness, budget impact analysis. Folliropin-alpha+lutropin-alpha cost of treating per one patient estimate 51 520 rubles, menotropin – 49 104 rubles, follitropin- alpa+menotropin - 61 298 rubles. Cost-effectiveness analysis, provided on the number of retrieved oocytes, rate of implantation and rate of clinical pregnancy, shown that follitropin-alpha+lutropin-alpha is dominant therapy. According to the results of the budget impact analysis, the increasing use of follitropin- alpha+lutropin-alpha on the market to 51.5% will save 29.2 million rubles.

Krylov V.A. 290

This article describes the currently used methods of indirect comparisons. The possibilities of using adjusted indirect comparison by the «Bucher method» are considered in detail. An indirect comparison of menotropin vs follitropin - alpha + menotropin is performed on the K. Buhler clinical trial. The indirect comparison showed no statistically significant differences between menotropin and follitropin-alpha + menotropin: OR=0.92 (0.68; 1.24), RR=0.93 (0.71;1.21).