Krylov Vyacheslav Antonovich

Krylov V.A., Kulikov A.Y., Yagudina R.I. 1355

Infertility is successfully treated by IVF and ICSI methods. One of the most important stages in IVF protocol is control ovarian stimulation (COS). There are recombinant and menopausal drugs to develop and mature oocyte. In this article was compared the economic efficiency of follitropin-alpha+lutropin-alpha vs follitropin-alpa+menotropin vs menotropin based on cost-effectiveness, budget impact analysis. Folliropin-alpha+lutropin-alpha cost of treating per one patient estimate 51 520 rubles, menotropin – 49 104 rubles, follitropin- alpa+menotropin - 61 298 rubles. Cost-effectiveness analysis, provided on the number of retrieved oocytes, rate of implantation and rate of clinical pregnancy, shown that follitropin-alpha+lutropin-alpha is dominant therapy. According to the results of the budget impact analysis, the increasing use of follitropin- alpha+lutropin-alpha on the market to 51.5% will save 29.2 million rubles.

Krylov V.A. 888

This article describes the currently used methods of indirect comparisons. The possibilities of using adjusted indirect comparison by the «Bucher method» are considered in detail. An indirect comparison of menotropin vs follitropin - alpha + menotropin is performed on the K. Buhler clinical trial. The indirect comparison showed no statistically significant differences between menotropin and follitropin-alpha + menotropin: OR=0.92 (0.68; 1.24), RR=0.93 (0.71;1.21).

Krylov V.A. 25

This article describes the differences in approaches to the reimbursement of IVF procedures in different countries. A comparative analysis of the regulatory framework has shown that in the EU countries there is a tendency to curb government spending by introducing restrictions on the total number of reimbursable cycles and the introduction of co-payments from patients. There is no federal law in the United States regulating the reimbursement of funds spent on assisted reproductive technologies, but 15 states have a mandate to cover infertility treatment. In Australia, financial support for married couples is provided when their own annual expenses for infertility treatment exceed one thousand Australian dollars. In Russia, a patient with infertility can receive two IVF cycles per year, but the total number of repeated cycles funded by the OMI is not limited.

Krylov V.A., Kulikov A.Y., Yagudina R.I. 1355

Infertility is successfully treated by IVF and ICSI methods. One of the most important stages in IVF protocol is control ovarian stimulation (COS). There are recombinant and menopausal drugs to develop and mature oocyte. In this article was compared the economic efficiency of follitropin-alpha+lutropin-alpha vs follitropin-alpa+menotropin vs menotropin based on cost-effectiveness, budget impact analysis. Folliropin-alpha+lutropin-alpha cost of treating per one patient estimate 51 520 rubles, menotropin – 49 104 rubles, follitropin- alpa+menotropin - 61 298 rubles. Cost-effectiveness analysis, provided on the number of retrieved oocytes, rate of implantation and rate of clinical pregnancy, shown that follitropin-alpha+lutropin-alpha is dominant therapy. According to the results of the budget impact analysis, the increasing use of follitropin- alpha+lutropin-alpha on the market to 51.5% will save 29.2 million rubles.

Krylov V.A. 888

This article describes the currently used methods of indirect comparisons. The possibilities of using adjusted indirect comparison by the «Bucher method» are considered in detail. An indirect comparison of menotropin vs follitropin - alpha + menotropin is performed on the K. Buhler clinical trial. The indirect comparison showed no statistically significant differences between menotropin and follitropin-alpha + menotropin: OR=0.92 (0.68; 1.24), RR=0.93 (0.71;1.21).

Krylov V.A. 25

This article describes the differences in approaches to the reimbursement of IVF procedures in different countries. A comparative analysis of the regulatory framework has shown that in the EU countries there is a tendency to curb government spending by introducing restrictions on the total number of reimbursable cycles and the introduction of co-payments from patients. There is no federal law in the United States regulating the reimbursement of funds spent on assisted reproductive technologies, but 15 states have a mandate to cover infertility treatment. In Australia, financial support for married couples is provided when their own annual expenses for infertility treatment exceed one thousand Australian dollars. In Russia, a patient with infertility can receive two IVF cycles per year, but the total number of repeated cycles funded by the OMI is not limited.