Kulikov A.Y., Serpik V.G., Yagudina R.I. 418

Methodological issues of computations of the entry and distribution of patients and determining the course dose of drugs in pharmacoeconomic models

This article discusses the issues of pharmacoeconomic modeling related to the description of the movement of patients in the pharmacoeconomic model, as well as approaches to determining the course dose of drugs under the condition of integer calculations. In particular, we described two possible ways of distributing patients between treatment regimens in pharmacoeconomic models, also analyzed the effects of simultaneous and uniform entry of patients into the model. As part of the issue of determining the course dose of a drug, we described the limitations and possibilities of calculations based on the active substance and packaging, as well as the transition factor of the remainder of the drug in the next time period.
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