en - Pharmacoeconomics: theory and practice

Pharmacoeconomics: theory and practice

Russian studies

Makarova E.I., Yagudina R.I. 694

Methodology of calculation of QALY in pharmacoeconomic modelling: using questionnaires of study of patient’s quality of life

This article presents a methodology for calculating QALY using questionnaires to study the quality of life of a patient. The review and classification of the most frequently used questionnaires of quality of life measurement validated to QALY are presented, their main features, advantages and disadvantages are highlighted. The main elements of universal questionnaires, as well as the stages of obtaining the utility index, are described in detail. In addition, alternative methods to obtaining health state utility values for generic questionnaires have been explored, using forecasting (mapping) based on data on other indicators of the patient’s health status.

.., Balykina Y.E., Gomon Y.M., Ivanov V.V., Kolbin A.S., .., .., .. 675

Complicated intra-abdominal infection at multidisciplinary hospital: economics of real practice of antimicrobial treatment

Aim: To assess economic efficiency of complicated intra-abdomibal infections treatment in real practice compared to alternative scenario (treatment with carbapenem Ertapanem) taking in to account E. coli resistance. Methods: Cost-effectiveness analysis were performed. Mathematic modelling was done to assess prognosis of bacterial resistance. Results: Cost of 1 case of complicated intra-abdomibal infections in real practice is 83048,08 rub compared to 91706,06 rub according to alternative strategy. Cost-effectiveness analysis revealed that real practice of treatment intra-abdomibal infections dominated alternative scenario: less effectiveness lead to lower cost. Additional effectiveness (1,95%) demand additionally 443316,97 rub. Taking into account dynamic of E. Coli resistance ICER during 2011-2015 period decreased up to 40%. Conclusion: Antimicrobial resistance of bacterial agents is important criteria which should be used to estimate economic effectiveness of any medical strategy. Key words: complicated intra-abdominal infection, bacterial resistance, pharmacoeconomic analysis

.. 660

Pharmacy reimbursement and pharmacoeconomic aspects of therapy of bronchial asthma

Bronchial asthma (BA) is an urgent public health problem. Treatment of asthma is based on the level of disease control. The change in the structure of basic therapy and the replacement of inhalers are the main causes of exacerbations of asthma and an increase in material costs. «Symbicort Maintenance And Reliever Therapy» (SMART) promote effective control of asthma: providing monitoring and decrease future risk of exacerbation. Improving control of asthma will reduce the steroid load, to reduce the number of hospitalizations and the number of ambulance calls. Key words: bronchial asthma, preferential provision of medicines, combined basic therapy, efficiency

Serpik V.G., Yagudina R.I. 244

Pharmacoeconomic evaluation of treatment of gastric cancer with ramucirumab in second line

Abstract: We provided a pharmacoeconomic evaluation of the treatment of gastric cancer in the second line of therapy with ramucirumab, using the relative value analysis method. Ramucirumab is the only anti-angiogenic drug registered for the treatment of advanced gastric cancer. In comparison with the standard regimens of the second line of chemotherapy for gastric cancer, the use of the ramucirumab has a statistically significant advantage, increasing the median overall survival by 30%. Ramucirumab (Cyramza) cost of treating per one patient is 1 761 564 RUB. From the perspective of relative value analysis the cost of an additional unit of effectiveness of ramucirumab is comparable or even lower than the same criteria of other antitumor drugs of monoclonal antibodies already included in the national EDL. Consequently, ramucirumab can be characterized as an acceptable technology. The budget impact analysis showed that providing patients with advanced gastric cancer with the ramucirumab is characterized by a lower burden on the drug support budget for oncological patients than bevacizumab, trastuzumab and cetuximab in the therapy of the oncology nosologies, at the their approval date. According to the results of the budget impact analysis on the drug supply of ramucirumab, 200 patients will additionally require 329.19 million rubles, which is only 0.64% of the budget for the treatment of cancer in 2016. Key words: gastric cancer, pharmacoeconomics, cost-effectiveness analysis, budget impact analysis, relative value analysis, bevacizumab, cetuximab, ramucirumab, trastuzumab.

Congress materials

Nosova P.S., Reshetko O.V., Rizhenkova I.G. 244

Pharmacoepidemiological analysis of the combined use of antipsychotics and antidepressants for inpatient treatment of schizophrenia

Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

Dorfman I.P., Orlova E.A., .., Umerova A.R. 246

Vaccination of patients with chronic obstructive pulmonary disease (copd): results of questionnaires of doctors of polyclinics

Astrakhan State Medical University, Astrakhan, Russia

Kabakova T.I., Prokopenko V.V. 229

The analysis of medical appointments to patients with the diagnosis a pollinosis and an allergic rhinitis

Pyatigorsk Medical Pharmaceutical Institute of Volgograd Medical State University, Pyatigorsk, Russia

Kuznesov D.A., Pupchenko G.P. 234

Using the principles of pharmacoeconomics in drug supply in pediatrics

First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Ryagina V.A., .., Yagudina R.I. 222

The relevance of socio-economic evaluation of the application monoclonal antibodies in the treatment of bronchial asthma

First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Abdurachmanov A.K., Ardenova N.N., .., Babaev V.D., Levitan A.I., Reshetko O.V. 245

Pharmacoepidemiological analysis of diabetic foot syndrome treatment in hospital

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

.., Babiy V.V., Levitan A.I., Novikov D.E., Reshetko O.V. 231

Use of antibiotics for the diabetic foot syndrome treatment in hospital

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Arkhipova E.I., Reshetko O.V., Yakovlev D.S. 228

Analysis of antibacterial therapy of community-acquired pneumonia in children in hospital

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Gribkova I.., Davidovskaya M.V., Dubovtseva V.A., Ermolaeva T.N., Kokushkin K.A., Poljakova K.I., .., Stepanova V.N., .., Holovnja-Voloskova M.J., .. 239

Comparative pharmacoeconomic analysis of the drug sorbifer durules and ferric iron preparations for the treatment and prevention of iron deficiency anemia pregnant

Clinical Trials and Healthcare Technology Assessment Centre of Moscow Department of Healthcare, Moscow, Russia

Bat N.M., Pavlyuchenko I..., Tugus N.S. 234

Marketing and pharmacoeconomic analysis of the regional pharmaceutical market off medicinal drugs with antioxidant and antihypoxic action

1 Kuban State Medical University, Krasnodar, Russia 2 Kuban State Agrarian University named afer I.T. Trubilin, Krasnodar, Russia

Davidovskaya M.V., Ermolaeva T.N., Kokushkin K.A., Fisun A.G., Holovnja-Voloskova M.J. 219

Risk sharing agreements - international and russian experience

Clinical Trials and Healthcare Technology Assessment Centre of Moscow Department of Healthcare, Moscow, Russia

Davidovskaya M.V., Lipatova T.E., .., Malinova L.I., Reshetko O.V., Furman N.V. 232

Analysis of awareness of practice doctors-cardiologists about contemporary principles of antiagregant therapy

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Dremova N.B. 243

The problems of medication compliance at modern patients

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Goncharova R.K., .., Eliseeva E.V., .., Eremeeva V.A., .., Манеева Е.С. 221

Analysis of the use of antituberculosis drugs in hospital

Pacifc State Medical University, Vladivostok, Russia

Kabakova T.I., Kalinin I.V. 228

Problems of organization of drug supply hiv-infected people in the regional prison health care organizations

Pyatigorsk Medical Pharmaceutical Institute of Volgograd Medical State University, Pyatigorsk, Russia

Dorfman I.P., Kirilochev O.O., Umerova A.R. 233

Anticholinergic load and financial burden: is there a point of contact?

Pyatigorsk Medical Pharmaceutical Institute of Volgograd Medical State University, Pyatigorsk, Russia

Klimova A.I., .., Levitan A.I., Reshetko O.V., Rizhenkova I.G. 237

Microflora of patients biomaterials in resuscitation department and its sensitivity to antibiotics

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

klishchenko M.Y., Kuznetsov D.A. 232

The role of pharmacoeconomic competencies in ensuring personnel security

Ryazan State Medical University, Ryazan, Russia

klishchenko M.Y., Koretskaya L.V. 204

The forming of skills at the students of pharmaceutical faculty for organization of work in hospital pharmacy

Ryazan State Medical University, Ryazan, Russia

Kostina E.O., .., Yagudina R.I. 219

The relevance of the clinical and economic evaluation of insulin pump in the treatment diabetes mellitus

Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Krylov A.B., Yagudina R.I. 227

The relevance of the clinical and economic evaluation of medicines used in in vitro fertilization (ivf) in Russian Federation

Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Kulikov A.Y., Protsenko M.V. 236

Budget impact analysis of phosphate binders hyperphosphatemia therapy in patient with chronic kidney disease

First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

.., Magdeev R.M., Reshetko O.V. 224

Pharmacoepidemiology of hypolipidemic therapy in patients with metabolic syndrome in real clinical practice

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Bulacheva A.Y., .., Goncharova R.K., Eliseeva E.V., Eremeeva V.A., Манеева Е.С. 235

Clinical and economic analysis is the basis for optimization of preferential medicinal providing

Pacifc State Medical University, Vladivostok, Russia

Eliseeva E.V., Eremeeva V.A., Манеева Е.С., Poddubny E.A., .., Feoktistova Y..., .. 229

Normative and legal aspects and problems of preferential medicinal providing of citizens

Pacifc State Medical University, Vladivostok, Russia

Golubenko R.A., Miroshnichenko Y.V., Scherba M.P. 224

The substantiation and development of the model of rational drug supply for individual categories of citizens in the framework of military and civil health care

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Novokreshenova I.G., Reshetko O.V., Yakimova Y.N. 225

Doctors knowledge on antibiotics for systematic application

Ryazan State Medical University, Ryazan, Russia

Kharchenko G.. 221

Factors affecting the acquisition of tonometers

Ryazan State Medical University, Ryazan, Russia

Davydovskaya M.V., Ermolaeva T.N., Kokushkin K.A., Tolkushin A.G., Yagudina R.I. 236

Av analysis. the method of consolidation of limited budgetary opportunities and growing needs in innovative medicines

1 Clinical Trials and Healthcare Technology Assessment Centre of Moscow Department of Healthcare, Moscow, Russia 2 First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Buzina O.R., .., Kirilochev O.O., Umerova A.R. 238

Pharmacoepidemiological and pharmacoeconomical aspects of the prevention of adverse drug reactions

Astrakhan State Medical University, Astrakhan, Russia

Levitan A.I., Reshetko O.V., Suleymanova R.R., .., Tuluzakova N.A., .. 230

Analysis of drug therapy of osteoporosis in rheumatic patients

Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

Kuznesov D.A., Semyonova S.V., .. 233

Features of pharmaceutical marketing audit

First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Reshetko O.V., Rizhenkova I.G., Sokolov A.V. 231

Pattern of antithrombotic drugs in hospital treatment of atrial fibrillation

First Moscow State Medical University I.M. Sechenov (Sechenov University), Moscow, Russia

Kostenko N.L., Miroshnichenko Y.V., Scherba M.P. 232

On the application of petri networks for modeling of pharmacoeconomic research

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Kononov V.N., Miroshnichenko Y.V., Scherba M.P. 241

The substantiation of rational economic and pharmaceutical mechanisms of drug supply for categories of citizens attached to military medical organizations

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Levitan A.I., Musaeva Z.T., .., Reshetko O.V. 221

Pharmacoepidemiological analysis of pharmacotherapy for osteoarthritis in hospital

Saratov State Medical University named afer V.I. Razumovsky, Saratov, Russia

Geller L.N., .., Mymrina A.L., .., Skripko A.A., .. 224

Assessment of pharmaceutical safety of patients at the hospital level

1 Novokuznetsk State Institute for Further Training of Physicians, Novokuznetsk, Russia 2 Irkutsk State Medical University, Irkutsk, Russia

Vinogradova I.A., Davydovskaya M.V., Kokushkin K.A., Lobanova N.A., .., Markarjan V.G., .., Nikitin E.A., .., Ptushkin V.V., .., Sharkunov N.N., .., Shihbabaeva D.I., .. 262

Hodgkin lymphoma therapy in practical health care: analysis of the hospital register of city clinical hospital named after S.P. Botkin

1 City clinical hospital named afer S.P. Botkin, Moscow, Russia 2 Clinical Trials and Healthcare Technology Assessment Centre of Moscow Department of Healthcare, Moscow, Russia